GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways

López‐Isac, Elena; Acosta‐Herrera, Marialbert; Kerick, Martin; Assassi, Shervin; T. Satpathy, Ansuman; M. Granja, Jeffrey; R. Mumbach, Maxwell; Beretta, Lorenzo; Pilar Simeón‐Aznar, Carmen; Carreira, Patrícia; Ortego‐Centeno, Norberto; Castellví, I.; Bossini‐Castillo, Lara; David Carmona, F.; Orozco, Gisela; Hunzelmann, Nicolas; H. W. Distler, Jörg; Franke, André; Lunardi, Claudio; Moroncini, Gianluca; Gabrielli, Armando; de Vries‐Bouwstra, Jeska; Wijmenga, Cisca; P. C. Koeleman, Bobby; Nordin, Annika; Padyukov, Leonid; Hoffmann‐Vold, Anna‐Maria; A. Lie, Benedicte; Scleroderma Group†, European; Rios, Raimon; Luís Callejas-Rubio, José; Antonio Vargas‐Hitos, José; García-Portales, Rosa; T Camps, M; Fernández‐Nebro, Antonio; González-Escribano, Marı́a-Francisca; José García Hernández, Francisco; Jesús Castillo, María; Á. Aguirre, M.; Gómez-Gracia, Inmaculada; Fernández‐Gutiérrez, Benjamín; Rodríguez‐Rodríguez, Luis; García de la Peña, Paloma; Vicente, Esther; Luís Andreu, José; Fernández Castro, M.; Javier López-Longo, Francisco; Quintanilla Martinez, Leticia; , Fonollosa; Guillén, Alberto; Espinosa, Gerard; Tolosa, Carlos; Pros, A.; Rodríguez‐Carballeira, Mónica; Narváez, Javier; Rubio‐Rivas, Manuel; , Ortiz-Santamaría; Belén Madroñero, Ana; Á. González‐Gay, Miguel; J. Diaz, Bianca; Trapiella, Luis; M. M. Sousa, André; V. Egurbide, M.; Fanlo-Mateo, P.; Sáez-Comet, Luís; Díez Díaz, Fidel; , Hernández; Beltrán, E.; Andrés Román-Ivorra, José; Grau, Elena; José Alegre Sancho, Juan; Freire, M.; J. Blanco, Francisco; Oreiro, N.; Witte, Torsten; Kreuter, Alexander; Riemekasten, G.; Airó, Paolo; Magro, C.; E. Voskuyl, Alexandre; C. Vonk, M.; Hesselstrand, Roger; Proudman, Susanna; Stevens, Wendy; Nikpour, Mandana; Scleroderma Interest Group (ASIG), Australian; Zochling, Jane; Sahhar, J.; Roddy, Janet; Nash, Peter; Tymms, Kathleen; Rischmueller, Maureen; Lester, Sue; J. Vyse, Timothy; L. Herrick, Ariane; Worthington, Jane; P. Denton, Christopher; Allanore, Yannick; A. Brown, Matthew; R. D. J. Radstake, Timothy; Fonseca, Carmen; Y. Chang, Howard; D. Mayes, Maureen; Martı́n, Javier

doi:10.1038/s41467-019-12760-y

Public

GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways

Published in Nature Communications • Oct 31, 2019

Authors:

Elena López‐Isac

Marialbert Acosta‐Herrera

Martin Kerick

Abstract

Systemic sclerosis (SSc) is an autoimmune disease that shows one of the highest mortality rates among rheumatic diseases. We perform a large genome-wide association study (GWAS), and meta-analysis with previous GWASs, in 26,679 individuals and identify 27 independent genome-wide associated signals, ...

Subject

Genome-wide association study

Multiple sclerosis

Medicine

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