Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer’s brain tissue

Kollmer, Marius; Close, William; Funk, Leonie; Rasmussen, Jay; Bsoul, Aref; Schierhorn, Angelika; Schmidt, Matthias; J. Sigurdson, Christina; Jucker, Mathias; Fändrich, Marcus

doi:10.1038/s41467-019-12683-8

Public

Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer’s brain tissue

Published in Nature Communications • Oct 29, 2019

Authors:

Marius Kollmer

William Close

Leonie Funk

Abstract

The formation of Aβ amyloid fibrils is a neuropathological hallmark of Alzheimer's disease and cerebral amyloid angiopathy. However, the structure of Aβ amyloid fibrils from brain tissue is poorly understood. Here we report the purification of Aβ amyloid fibrils from meningeal Alzheimer's brain tiss...

Subject

Fibril

Cerebral amyloid angiopathy

Amyloid (mycology)

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