Genetic Ablation of TASK-1 (Tandem of P Domains in a Weak Inward Rectifying K + Channel–Related Acid-Sensitive K + Channel-1) (K 2P 3.1) K + Channels Suppresses Atrial Fibrillation and Prevents Electrical Remodeling

Schmidt, Constanze; Wiedmann, Felix; Beyersdorf, Christoph; Zhao, Zhihan; El‐Battrawy, Ibrahim; Lan, Huan; Szabó, Gábor; Li, Xin; Lang, Siegfried; Korkmaz‐Icöz, Sevil; Rapti, Kleopatra; Jungmann, Andreas; Ratte, Antonius; J. Müller, Oliver; Karck, Matthias; Seemann, Gunnar; Akın, İbrahim; Borggrefe, Martin; Zhou, Xiaobo; A. Katus, Hugo; Thomas, Dierk

doi:10.1161/circep.119.007465

Public

Genetic Ablation of TASK-1 (Tandem of P Domains in a Weak Inward Rectifying K + Channel–Related Acid-Sensitive K + Channel-1) (K 2P 3.1) K + Channels Suppresses Atrial Fibrillation and Prevents Electrical Remodeling

Published in Circulation Arrhythmia and Electrophysiology • Sep 1, 2019

Authors:

Constanze Schmidt

Felix Wiedmann

Christoph Beyersdorf

Abstract

Background: Despite an increasing understanding of atrial fibrillation (AF) pathophysiology, translation into mechanism-based treatment options is lacking. In atrial cardiomyocytes of patients with chronic AF, expression, and function of tandem of P domains in a weak inward rectifying TASK-1 (K + ch...

Subject

Sinus rhythm

Atrial fibrillation

Internal medicine

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