Quercetin prevents necroptosis of oligodendrocytes by inhibiting macrophages/microglia polarization to M1 phenotype after spinal cord injury in rats.

Hong, Fan,; Hai-Bin, Tang,; Le-Qun, Shan,; Shi-Chang, Liu,; Da-Geng, Huang,; Xun, Chen,; Zhe, Chen,; Ming, Yang,; Xin-Hua, Yin,; Hao, Yang,; Ding-Jun, Hao,

doi:10.1186/s12974-019-1613-2

Public

Quercetin prevents necroptosis of oligodendrocytes by inhibiting macrophages/microglia polarization to M1 phenotype after spinal cord injury in rats.

Published in Journal of neuroinflammation • Nov 7, 2019

Authors:

Fan, Hong

Tang, Hai-Bin

Shan, Le-Qun

Abstract

BACKGROUND: Oligodendrocytes (OLs) death after spinal cord injury (SCI) contributes to demyelination, even leading to a permanent neurological deficit. Besides apoptosis, our previous study demonstrated that OLs underwent receptor-interacting serine-threonine kinase 3(RIP3)/mixed lineage kinase doma...

Subject

Macrophages/microglia

Necroptosis

Oligodendrocyte

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