Efficacy of Pembrolizumab in Patients With Noncolorectal High Microsatellite Instability/Mismatch Repair–Deficient Cancer: Results From the Phase II KEYNOTE-158 Study

Marabelle, Aurélien; T. Le, Dung; A. Ascierto, Paolo; Maria Di Giacomo, Anna; De Jesus‐Acosta, Ana; Delord, Jean-Pierre; Geva, Ravit; Gottfried, Maya; Penel, Nicolas; R. Hansen, Aaron; A. Piha‐Paul, Sarina; Doi, Toshihiko; Gao, Bo; Cheol Chung, Hyun; A. López-Martín, José; Bang, Yung-Jue; Shapira Frommer, Ronnie; H. Shah, Manisha; Ghori, Razi; K. Joe, Andrew; K. Pruitt, Scott; A. Díaz, Luis

doi:10.1200/jco.19.02105

Public

Efficacy of Pembrolizumab in Patients With Noncolorectal High Microsatellite Instability/Mismatch Repair–Deficient Cancer: Results From the Phase II KEYNOTE-158 Study

Published in Journal of Clinical Oncology • Nov 4, 2019

Authors:

Aurélien Marabelle

Dung T. Le

Paolo A. Ascierto

Abstract

PURPOSE: Genomes of tumors that are deficient in DNA mismatch repair (dMMR) have high microsatellite instability (MSI-H) and harbor hundreds to thousands of somatic mutations that encode potential neoantigens. Such tumors are therefore likely to be immunogenic, triggering upregulation of immune chec...

Subject

Pembrolizumab

Medicine

Microsatellite instability

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