STAT3 activation through IL-6/IL-11 in cancer-associated fibroblasts promotes colorectal tumour development and correlates with poor prognosis

Heichler, Christina; Scheibe, Kristina; Schmied, Anabel; Geppert, Carol; Schmid, Benjamin; Wirtz, Stefan; Thoma, Oana‐Maria; Kramer, Viktoria; J. Waldner, Maximilian; Büttner, Christian; F. Farin, Henner; Pešić, Marina; Knieling, Ferdinand; Merkel, Susanne; Grüneboom, Anika; Gunzer, Matthias; Grützmann, Robert; Rose‐John, Stefan; B. Koralov, Sergei; Kollias, George; Vieth, Michael; Hartmann, Arndt; R. Greten, Florian; F. Neurath, Markus; Neufert, Clemens

doi:10.1136/gutjnl-2019-319200

Public

STAT3 activation through IL-6/IL-11 in cancer-associated fibroblasts promotes colorectal tumour development and correlates with poor prognosis

Published in Gut • Nov 4, 2019

Authors:

Christina Heichler

Kristina Scheibe

Anabel Schmied

Abstract

OBJECTIVE: Cancer-associated fibroblasts (CAFs) influence the tumour microenvironment and tumour growth. However, the role of CAFs in colorectal cancer (CRC) development is incompletely understood. DESIGN: We quantified phosphorylation of STAT3 (pSTAT3) expression in CAFs of human colon cancer tissu...

Subject

Cancer-Associated Fibroblasts

Colorectal cancer

Stromal cell

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