Valproic acid targets HDAC1/2 and HDAC1/PTEN/Akt signalling to inhibit cell proliferation via the induction of autophagy in gastric cancer

Sun, Jie; Piao, Junjie; Li, Nan; Yang, Yang; Kim, Ki‐Yeol; Lin, Zhenhua

doi:10.1111/febs.15122

Public

Valproic acid targets HDAC1/2 and HDAC1/PTEN/Akt signalling to inhibit cell proliferation via the induction of autophagy in gastric cancer

Published in FEBS Journal • Nov 6, 2019

Authors:

Jie Sun

Junjie Piao

Nan Li

Abstract

Valproic acid (2-propylpentanoic acid, VPA) has been widely used as an anticonvulsant drug and is a choice drug for seizure treatment. VPA is also used as a short-chain fatty acid HDAC inhibitor that affects proliferation and differentiation and induces cell apoptosis in both solid and haematologic ...

Subject

Autophagy

PTEN

Cancer research

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