Mitochondrial damage by α-synuclein causes cell death in human dopaminergic neurons

K. Ganjam, Goutham; Bolte, Kathrin; A. Matschke, Lina; Neitemeier, Sandra; M. Dolga, Amalia; Höllerhage, Matthias; U. Höglinger, Günter; Adamczyk, Agata; Decher, Niels; H. Oertel, Wolfgang; Culmsee, Carsten

doi:10.1038/s41419-019-2091-2

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Mitochondrial damage by α-synuclein causes cell death in human dopaminergic neurons

Shared by NobleBlocks on Nov 14, 2019 • 12:00 AM UTC

Authors:

Goutham K. Ganjam

Kathrin Bolte

Lina A. Matschke

Abstract

Abstract Evolving concepts on Parkinson’s disease (PD) pathology suggest that α-synuclein (aSYN) promote dopaminergic neuron dysfunction and death through accumulating in the mitochondria. However, the consequence of mitochondrial aSYN localisation on mitochondrial structure and bioenergetic functio...

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