Adipose tissue NAD <sup>+</sup> biosynthesis is required for regulating adaptive thermogenesis and whole-body energy homeostasis in mice

Yamaguchi, Shintaro; P. Franczyk, Michael; Chondronikola, Maria; Qi, Nathan; C. Gunawardana, Subhadra; L. Stromsdorfer, Kelly; C. Porter, Lane; F. Wozniak, David; Sasaki, Yo; Rensing, Nicholas; Wong, Michael; W. Piston, David; Klein, Samuel; Yoshino, Jun

doi:10.1073/pnas.1909917116

Public

Adipose tissue NAD + biosynthesis is required for regulating adaptive thermogenesis and whole-body energy homeostasis in mice

Published in Proceedings of the National Academy of Sciences • Nov 6, 2019

Authors:

Shintaro Yamaguchi

Michael P. Franczyk

Maria Chondronikola

Abstract

Nicotinamide adenine dinucleotide (NAD + ) is a critical coenzyme for cellular energy metabolism. The aim of the present study was to determine the importance of brown and white adipose tissue (BAT and WAT) NAD + metabolism in regulating whole-body thermogenesis and energy metabolism. Accordingly, w...

Subject

NAD+ kinase

Thermogenesis

Brown adipose tissue

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