Mechanisms of Relapse After CD19 CAR T-Cell Therapy for Acute Lymphoblastic Leukemia and Its Prevention and Treatment Strategies

Xu, Xinjie; Sun, Qihang; Liang, Xiaoqian; Chen, Zitong; Zhang, Xiaoli; Zhou, Xuan; Li, Meifang; Tu, Huilin; Liu, Yu; Tu, Sanfang; Li, Yuhua

doi:10.3389/fimmu.2019.02664

Public

Mechanisms of Relapse After CD19 CAR T-Cell Therapy for Acute Lymphoblastic Leukemia and Its Prevention and Treatment Strategies

Published in Frontiers in Immunology • Nov 12, 2019

Authors:

Xinjie Xu

Qihang Sun

Xiaoqian Liang

Abstract

Chimeric antigen receptor (CAR) T-cell therapy is highly effective in the treatment of B-cell acute lymphoblastic leukemia (ALL) or B-cell lymphoma, providing alternative therapeutic options for patients who failed to respond to conventional treatment or relapse. Moreover, it can bridge other therap...

Subject

Chimeric antigen receptor

CD19

Medicine

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