Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

R. I. Coleman, Jonathan; J. Peyrot, Wouter; L. Purves, Kirstin; A. S. Davis, Katrina; Rayner, Christopher; Wan Choi, Shing; Hübel, Christopher; A. Gaspar, Héléna; Kan, Carol; Van der Auwera, Sandra; J. Adams, Mark; M. Lyall, Donald; W. Choi, Karmel; R. Wray, Naomi; Ripke, Stephan; Mattheisen, Manuel; Trzaskowski, Maciej; M. Byrne, Enda; Abdellaoui, Abdel; J. Adams, Mark; Agerbo, Esben; Air, Tracy; F. M. Andlauer, Till; Bacanu, Silviu‐Alin; Bækvad‐Hansen, Marie; T.F. Beekman, Aartjan; B. Bigdeli, Tim; B. Binder, Elisabeth; Bryois, Julien; N. Buttenschøn, Henriette; Bybjerg‐Grauholm, Jonas; Cai, Na; Castelao, Enrique; Christensen, Jane; Clarke, Toni‐Kim; R. I. Coleman, Jonathan; Colodro‐Conde, Lucía; Couvy‐Duchesne, Baptiste; Craddock, Nick; E. Crawford, Gregory; Davies, Gail; J. Deary, Ian; Degenhardt, Franziska; M. Derks, Eske; Direk, Neşe; V. Dolan, Conor; C. Dunn, Erin; C. Eley, Thalia; Escott‐Price, Valentina; Farhadi Hassan Kiadeh, Farnush; K. Finucane, Hilary; C. Foo, Jerome; J. Forstner, Andreas; Frank, Josef; A. Gaspar, Héléna; Gill, Michael; S. Goes, Fernando; D. Gordon, Scott; Grove, Jakob; S. Hall, Lynsey; Søholm Hansen, Christine; Folkmann Hansen, Thomas; Herms, Stefan; B. Hickie, Ian; Hoffmann, Per; Homuth, Georg; Horn, Carsten; Hottenga, Jouke‐Jan; M. Hougaard, David; M. Howard, David; Ising, Marcus; Jansen, Rick; Jones, Ian; Jones, Lisa; Jorgenson, Eric; A. Knowles, James; S. Kohane, Isaac; Kraft, Julia; W. Kretzschmar, Warren; Kutalik, Zoltán; Li, Yihan; A. Lind, Penelope; J. MacIntyre, Donald; F. MacKinnon, Dean; Maier, Robert; Maier, Wolfgang; Marchini, Jonathan; Mbarek, Hamdi; J. McGrath, Patrick; McGuffin, Peter; E. Medland, Sarah; Mehta, Divya; M. Middeldorp, Christel; Mihailov, Evelin; Milaneschi, Yuri; Milani, Lili; M. Mondimore, Francis; W. Montgomery, Grant; Mostafavi, Sara; Mullins, Niamh; Nauck, Matthias; Ng, Bernard; G. Nivard, Michel; R. Nyholt, Dale; F. O’Reilly, Paul; Óskarsson, Högni; J. Owen, Michael; N. Painter, Jodie; Bøcker Pedersen, Carsten; Giørtz Pedersen, Marianne; E. Peterson, Roseann; Pettersson, Erik; J. Peyrot, Wouter; Pistis, Giorgio; Posthuma, Daniëlle; A. Quiroz, Jorge; Qvist, Per; P. Rice, John; P. Riley, Brien; Rivera, Margarita; Saeed Mirza, Saira; A. Schoevers, Robert; C. Schulte, Eva; Shen, Ling; Shi, Jianxin; I. Shyn, Stanley; Sigurðsson, Engilbert; Sinnamon, Grant; H. Smit, Johannes; J. Smıth, Daniel; Stefánsson, Hreinn; Steinberg, Stacy; Streit, Fabian; Strohmaier, Jana; E. Tansey, Katherine; Teismann, Henning; Teumer, Alexander; K. Thompson, Wesley; A. Thomson, Pippa; E. Thorgeirsson, Thorgeir; Traylor, Matthew; Treutlein, Jens; Trubetskoy, Vassily; G. Uitterlinden, André; Umbricht, Daniel; Van der Auwera, Sandra; M. van Hemert, Albert; Viktorin, Alexander; M. Visscher, Peter; Wang, Yunpeng; T. Webb, Bradley; Weinsheimer, Shantel; Wellmann, Jürgen; Willemsen, Gonneke; H. Witt, Stephanie; Wu, Yang; Simon Xi, Hualin; Yang, Jian; Zhang, Futao; Arolt, Volker; T. Baune, Bernhard; Berger, Klaus; I. Boomsma, Dorret; Cichon, Sven; Dannlowski, Udo; J. C. de Geus, Eco; Raymond DePaulo, J.; Domenici, Enrico; Domschke, Katharina; Esko, Tõnu; J. Grabe, Hans; P. Hamilton, Steven; Hayward, Caroline; C. Heath, Andrew; S. Kendler, Kenneth; Kloiber, Stefan; Lewis, Glyn; S. Li, Qingqin; Lucae, Susanne; A. F. Madden, Pamela; K. E. Magnusson, Patrik; G. Martin, Nicholas; M. McIntosh, Andrew; Metspalu, Andres; Mors, Ole; Bo Mortensen, Preben; Müller‐Myhsok, Bertram; Nordentoft, Merete; M. Nöthen, Markus; O‘Donovan, Michael; A. Paciga, Sara; L. Pedersen, Nancy; W.J.H. Penninx, Brenda; H. Perlis, Roy; J. Porteous, David; B. Potash, James; Preisig, Martin; Rietschel, Marcella; Schaefer, Catherine; G. Schulze, Thomas; W. Smoller, Jordan; Stefansson, Kari; Tiemeier, Henning; Uher, Rudolf; Völzke, Henry; M. Weissman, Myrna; Werge, Thomas; M. Lewis, Cathryn; F. Levinson, Douglas; Breen, Gerome; D. Børglum, Anders; F. Sullivan, Patrick; C. Dunn, Erin; Vassos, Evangelos; Danese, Andrea; Maughan, Barbara; J. Grabe, Hans; M. Lewis, Cathryn; F. O’Reilly, Paul; M. McIntosh, Andrew; J. Smıth, Daniel; R. Wray, Naomi; Hotopf, Matthew; C. Eley, Thalia; Breen, Gerome

doi:10.1038/s41380-019-0546-6

Public

Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

Published in Molecular Psychiatry • Jan 23, 2020

Authors:

Jonathan R. I. Coleman

Wouter J. Peyrot

Kirstin L. Purves

Abstract

Depression is more frequent among individuals exposed to traumatic events. Both trauma exposure and depression are heritable. However, the relationship between these traits, including the role of genetic risk factors, is complex and poorly understood. When modelling trauma exposure as an environment...

Subject

Biobank

Major depressive disorder

Psychology

Research Assistant

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