Cancer Risks Associated With Germline<i>PALB2</i>Pathogenic Variants: An International Study of 524 Families

Yang, Xin; Leslie, Goska; Doroszuk, Alicja; Schneider, Sandra; Allen, Jamie; Decker, Brennan; M. Dunning, Alison; Redman, James; Scarth, James; Plaskocinska, Inga; Luccarini, Craig; Shah, Mitul; Pooley, Karen; Dorling, Leila; Lee, Andrew; A. Adank, Muriel; Adlard, Julian; Aittomäki, Kristiina; L. Andrulis, Irene; Ang, Peter; Barwell, Julian; L. Bernstein, Jonine; Bobolis, Kristie; Borg, Åke; Blomqvist, Carl; B.M. Claes, Kathleen; Concannon, Patrick; Cuggia, Adeline; O. Culver, Julie; Damiola, Francesca; de Pauw, Antoine; Diez, Orland; S. Dolinsky, Jill; M. Domchek, Susan; Engel, Christoph; Gareth Evans, D.; Fostira, Florentia; Garber, Judy; Golmard, Lisa; L. Goode, Ellen; B. Gruber, Stephen; Hahnen, Eric; Hake, Christopher; Heikkinen, Tuomas; E. Hurley, Judith; Janavicius, Ramunas; Kleibl, Zdenek; Kleiblova, Petra; Konstantopoulou, Irene; Kvist, Anders; Laduca, Holly; S.G. Lee, Ann; Lesueur, Fabienne; R. Maher, Eamonn; Mannermaa, Arto; Manoukian, Siranoush; McFarland, Rachel; McKinnon, Wendy; Meindl, Alfons; Metcalfe, Kelly; Aishah Mohd Taib, Nur; Moilanen, Jukka; L. Nathanson, Katherine; Neuhausen, Susan; Sze Ng, Pei; Nguyen-Dumont, Tu; M. Nielsen, Sarah; Obermair, Florian; Offit, Kenneth; I. Olopade, Olufunmilayo; Ottini, Laura; Penkert, Judith; Pylkäs, Katri; Radice, Paolo; J. Ramus, Susan; Rudaitis, Vilius; Side, Lucy; Silva-Smith, Rachel; Silvestri, Valentina; Skytte, Anne-Bine; Slavin, Thomas; Soukupova, Jana; Tondini, Carlo; H. Trainer, Alison; Unzeitig, Gary; Usha, Lydia; van Overeem Hansen, Thomas; Whitworth, James; Wood, Marie; Har Yip, Cheng; Yoon, Sook-Yee; Yussuf, Amal; Zogopoulos, George; Goldgar, David; L. Hopper, John; Chenevix-Trench, Georgia; Pharoah, Paul; H.L. George, Sophia; Balmaña, Judith; Houdayer, Claude; James, Paul; El-Haffaf, Zaki; Ehrencrona, Hans; Janatova, Marketa; Peterlongo, Paolo; Nevanlinna, Heli; Schmutzler, Rita; Teo, Soo-Hwang; Robson, Mark; Pal, Tuya; Couch, Fergus; N. Weitzel, Jeffrey; Elliott, Aaron; Southey, Melissa; Winqvist, Robert; F. Easton, Douglas; D. Foulkes, William; C. Antoniou, Antonis; Tischkowitz, Marc

doi:10.1200/jco.19.01907

Public

Cancer Risks Associated With GermlinePALB2Pathogenic Variants: An International Study of 524 Families

Published in Journal of Clinical Oncology • Mar 1, 2020

Authors:

Xin Yang

,

Goska Leslie

,

Alicja Doroszuk

Abstract

PURPOSE To estimate age-specific relative and absolute cancer risks of breast cancer and to estimate risks of ovarian, pancreatic, male breast, prostate, and colorectal cancers associated with germline PALB2 pathogenic variants (PVs) because these risks have not been extensively characterized. METHO...

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