Sacubitril/Valsartan Across the Spectrum of Ejection Fraction in Heart Failure

D. Solomon, Scott; Vaduganathan, Muthiah; Claggett, Brian; Packer, Milton; R. Zile, Michael; Swedberg, Karl; L. Rouleau, Jean; A. Pfeffer, Marc; S. Desai, Akshay; H. Lund, Lars; Køber, Lars; S. Anand, Inder; K. Sweitzer, Nancy; C.M. Linssen, Gerard; Merkely, Béla; Luis Arango, Juan; Vinereanu, Dragoş; Chen, Chen-Huan; Senni, Michele; S. Sibulo, Antonio; А. Boytsov, S.; Shi, Victor; R. Rizkala, Adel; Lefkowitz, Martin; J.V. McMurray, John

doi:10.1161/circulationaha.119.044586

Public

Sacubitril/Valsartan Across the Spectrum of Ejection Fraction in Heart Failure

Published in Circulation • Nov 17, 2019

Authors:

Scott D. Solomon

Muthiah Vaduganathan

Brian Claggett

Abstract

Background: While disease-modifying therapies exist for heart failure (HF) with reduced left ventricular ejection fraction (LVEF), few options are available for patients in the higher range of LVEF (>40%). Sacubitril/valsartan has been compared with a renin-angiotensin-aldosterone–system inhibitor a...

Subject

Medicine

Ejection fraction

Sacubitril

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