In Vivo AAV-CRISPR/Cas9–Mediated Gene Editing Ameliorates Atherosclerosis in Familial Hypercholesterolemia

Zhao, Huan; Li, Yán; He, Lingjuan; Pu, Wenjuan; Yu, Wei; Li, Yi; Wu, Yanting; Xu, Chenming; Wei, Yuda; Ding, Qiurong; Song, Bao‐Liang; Huang, Hefeng; Zhou, Bin

doi:10.1161/circulationaha.119.042476

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In Vivo AAV-CRISPR/Cas9–Mediated Gene Editing Ameliorates Atherosclerosis in Familial Hypercholesterolemia

Published in Circulation • Nov 29, 2019

Authors:

Huan Zhao

Yán Li

Lingjuan He

Abstract

Background: Mutations in low-density lipoprotein (LDL) receptor ( LDLR ) are one of the main causes of familial hypercholesterolemia, which induces atherosclerosis and has a high lifetime risk of cardiovascular disease. The clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 syst...

Subject

LDL receptor

CRISPR

Familial hypercholesterolemia

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