Biomarker-guided antibiotic stewardship in suspected ventilator-associated pneumonia (VAPrapid2): a randomised controlled trial and process evaluation

P Hellyer, Thomas; F. McAuley, Daniel; Walsh, Timothy; Anderson, Niall; Conway Morris, Andrew; Singh, Suveer; Dark, Paul; Roy, Alistair; D. Perkins, Gavin; McMullan, Ronan; M. Emerson, Lydia; Blackwood, Bronagh; E. Wright, Stephen; Kefala, Kallirroi; O’Kane, Cecilia; Baudouin, Simon; Paterson, Ross; Rostron, Anthony; Agus, Ashley; Bannard‐Smith, Jonathan; Robin, Nicole; Welters, Ingeborg; Bassford, Christopher; Yates, Bryan; Spencer, Craig; Laha, Shondipon; Hulme, Jonathan; Bonner, Stephen; Linnett, Vanessa; Sonksen, Julian; Van Den Broeck, Tina; Boschman, Gert; James Keenan, DW; Scott, Jonathan; Joy Allen, A.; Phair, Glenn; Parker, Jennie; A Bowett, Susan; John Simpson, A.

doi:10.1016/s2213-2600(19)30367-4

Public

Biomarker-guided antibiotic stewardship in suspected ventilator-associated pneumonia (VAPrapid2): a randomised controlled trial and process evaluation

Published in The Lancet Respiratory Medicine • Dec 3, 2019

Authors:

Thomas P Hellyer

Daniel F. McAuley

Timothy Walsh

Abstract

BACKGROUND: Ventilator-associated pneumonia is the most common intensive care unit (ICU)-acquired infection, yet accurate diagnosis remains difficult, leading to overuse of antibiotics. Low concentrations of IL-1β and IL-8 in bronchoalveolar lavage fluid have been validated as effective markers for ...

Subject

Medicine

Bronchoalveolar lavage

Pneumonia

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