Phase 3 Efficacy Analysis of a Typhoid Conjugate Vaccine Trial in Nepal

Shakya, Mila; Colin-Jones, Rachel; Theiss-Nyland, Katherine; Voysey, Merryn; Pant, Dikshya; Smith, Nicola; Liu, Xinxue; Tonks, Susan; Mazur, Olga; G. Farooq, Yama; Clarke, Jenny; Hill, Jennifer; Adhikari, Anup; Dongol, Sabina; Karkey, Abhilasha; Bajracharya, Binod; Kelly, Sarah; Gurung, Meeru; Baker, Stephen; M. Neuzil, Kathleen; Shrestha, Shrijana; Basnyat, Buddha; J. Pollard, Andrew

doi:10.1056/nejmoa1905047

Public

Phase 3 Efficacy Analysis of a Typhoid Conjugate Vaccine Trial in Nepal

Published in New England Journal of Medicine • Dec 4, 2019

Authors:

Mila Shakya

Rachel Colin-Jones

Katherine Theiss-Nyland

Abstract

BACKGROUND: Typhi is a major cause of fever in children in low- and middle-income countries. A typhoid conjugate vaccine (TCV) that was recently prequalified by the World Health Organization was shown to be efficacious in a human challenge model, but data from efficacy trials in areas where typhoid ...

Subject

Typhoid fever

Salmonella typhi

Typhoid vaccine

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