Genetic landscape of adult Langerhans cell histiocytosis with lung involvement.

F, Jouenne; S, Chevret; E, Bugnet; E, Clappier; G, Lorillon; V, Meignin; A, Sadoux; S, Cohen; A, Haziot; A, How-Kit; C, Kannengiesser; C, Lebbé; D, Gossot; S, Mourah; A, Tazi

doi:10.1183/13993003.01190-2019

Public

Genetic landscape of adult Langerhans cell histiocytosis with lung involvement.

Shared by NobleBlocks on Feb 27, 2020 • 12:00 AM UTC

Authors:

Jouenne F

Chevret S

Bugnet E

Abstract

The clinical significance of the BRAF V600E mutation in adult Langerhans cell histiocytosis (LCH), including pulmonary Langerhans cell histiocytosis (PLCH), is not well understood. Similarly, the spectrum of molecular alterations involved in adult LCH has not been fully delineated. To address these ...

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