Antiplasmodial Activity of Nitroaromatic Compounds: Correlation with Their Reduction Potential and Inhibitory Action on Plasmodium falciparum Glutathione Reductase

Maroziené, Audronè; Lesanavičius, Mindaugas; Davioud–Charvet, Elisabeth; Aliverti, Alessandro; Grellier, Philippe; Šarlauskas, Jonas; Čėnas, Narimantas

doi:10.3390/molecules24244509

Public

Antiplasmodial Activity of Nitroaromatic Compounds: Correlation with Their Reduction Potential and Inhibitory Action on Plasmodium falciparum Glutathione Reductase

Published in Molecules • Dec 10, 2019

Authors:

Audronè Maroziené

Mindaugas Lesanavičius

Elisabeth Davioud–Charvet

Abstract

With the aim to clarify the mechanism(s) of action of nitroaromatic compounds against the malaria parasite Plasmodium falciparum, we examined the single-electron reduction by P. falciparum ferredoxin:NADP+ oxidoreductase (PfFNR) of a series of nitrofurans and nitrobenzenes (n = 23), and their abilit...

Subject

Plasmodium falciparum

Glutathione

Chemistry

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