RETRACTED ARTICLE: m6A mRNA methylation initiated by METTL3 directly promotes YAP translation and increases YAP activity by regulating the MALAT1-miR-1914-3p-YAP axis to induce NSCLC drug resistance and metastasis

Jin, Dan; Guo, Jiwei; Wu, Yan; Du, Jing; Yang, Lijuan; Wang, Xiaohong; Di, Weihua; Hu, Baoguang; An, Jiajia; Kong, Ling–Qun; Pan, Lei; Su, Guoming

doi:10.1186/s13045-019-0830-6

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RETRACTED ARTICLE: m6A mRNA methylation initiated by METTL3 directly promotes YAP translation and increases YAP activity by regulating the MALAT1-miR-1914-3p-YAP axis to induce NSCLC drug resistance and metastasis

Published in Journal of Hematology & Oncology • Dec 9, 2019

Authors:

Dan Jin

Jiwei Guo

Yan Wu

Abstract

Abstract Background METTL3 is an RNA methyltransferase that mediates m 6 A modification and is implicated in mRNA biogenesis, decay, and translation. However, the biomechanism through which METTL3 regulates MALAT1-miR-1914-3p-YAP axis activity to induce NSCLC drug resistance and metastasis is not ve...

Subject

Gene knockdown

Messenger RNA

MALAT1

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