Pancreatic cancer organoids recapitulate disease and allow personalized drug screening

Driehuis, Else; van Hoeck, Arne; Moore, Kat; Kolders, Sigrid; E. Francies, Hayley; Can Gulersonmez, M.; C.A. Stigter, Edwin; Burgering, Boudewijn; Geurts, Veerle; Gudelj Gračanin, Ana; Bounova, Gergana; H.M. Morsink, Folkert; G.J. Vries, Robert; F. Boj, Sylvia; H. van Es, Johan; Johan A. Offerhaus, G.; Kranenburg, Onno; J. Garnett, Mathew; F.A. Wessels, Lodewyk; Cuppen, Edwin; A.A. Brosens, Lodewijk; Clevers, Hans

doi:10.1073/pnas.1911273116

Public

Pancreatic cancer organoids recapitulate disease and allow personalized drug screening

Published in Proceedings of the National Academy of Sciences • Dec 9, 2019

Authors:

Else Driehuis

Arne van Hoeck

Kat Moore

Abstract

We report the derivation of 30 patient-derived organoid lines (PDOs) from tumors arising in the pancreas and distal bile duct. PDOs recapitulate tumor histology and contain genetic alterations typical of pancreatic cancer. In vitro testing of a panel of 76 therapeutic agents revealed sensitivities c...

Subject

Pancreatic cancer

Organoid

Medicine

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