The antimicrobial peptide ZY4 combats multidrug-resistant <i>Pseudomonas aeruginosa</i> and <i>Acinetobacter baumannii</i> infection

Mwangi, James; Yin, Yizhu; Gan, Wang; Yang, Min; Li, Ya; Zhang, Zhiye; Lai, Ren

doi:10.1073/pnas.1909585117

Public

The antimicrobial peptide ZY4 combats multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii infection

Published in Proceedings of the National Academy of Sciences • Dec 16, 2019

Authors:

James Mwangi

Yizhu Yin

Wang Gan

Abstract

Significance This work showed that a designed cyclic peptide ZY4 exhibits excellent activity against Pseudomonas aeruginosa and Acinetobacter baumannii . ZY4 not only inhibits planktonic growth and biofilm formation but also kills persister cells by permeabilizing bacterial membrane. ZY4 showed low ...

Subject

Acinetobacter baumannii

Pseudomonas aeruginosa

Microbiology

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