The antimicrobial peptide ZY4 combats multidrug-resistant
            <i>Pseudomonas aeruginosa</i>
            and
            <i>Acinetobacter baumannii</i>
            infection

Mwangi, James; Yin, Yizhu; Wang, Gan; Yang, Min; Li, Ya; Zhang, Zhiye; Lai, Ren

doi:10.1073/pnas.1909585117

Public

The antimicrobial peptide ZY4 combats multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii infection

Shared by NobleBlocks on Dec 16, 2019 • 12:00 AM UTC

Authors:

James Mwangi

Yizhu Yin

Gan Wang

Abstract

Significance This work showed that a designed cyclic peptide ZY4 exhibits excellent activity against Pseudomonas aeruginosa and Acinetobacter baumannii . ZY4 not only inhibits planktonic growth and biofilm formation but also kills persister cells by permeabilizing bacterial membrane. ZY4 showed low ...

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