The interferon-induced protein kinase R: the base of a riboprotein scaffolding regulating the human immunodeficiency virus.

Daher, Aı̈cha; P. Labbé, Roman; Radetskyy, Roman; Gatignol, Anne

doi:10.1684/vir.2017.0707

Public

The interferon-induced protein kinase R: the base of a riboprotein scaffolding regulating the human immunodeficiency virus.

Published in PubMed • Oct 1, 2017

Authors:

Aı̈cha Daher

Roman P. Labbé

Roman Radetskyy

Abstract

The interferon-induced RNA-activated Protein Kinase (PKR) targets the alpha subunit of the eukaryotic translation initiation factor 2 (eIF2α) whose phosphorylation blocks translation initiation of cellular and viral mRNAs. PKR is activated at the beginning of human immunodeficiency virus (HIV) infec...

Subject

Protein kinase R

Interferon

Biology

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