Tim-3 Hampers Tumor Surveillance of Liver-Resident and Conventional NK Cells by Disrupting PI3K Signaling.

Tan, Siyu; Xu, Yong; Wang, Zehua; Wang, Tixiao; Du, Xianhong; Song, Xiaojia; Guo, Xiaowei; Peng, Jiali; Zhang, Jie; Liang, Yan; Lu, Jinghui; Peng, Jun; Gao, Chengjiang; Wu, Zhuanchang; Li, Chunyang; Li, Nailin; Gao, Lifen; Liang, Xiaohong; Ma, Chunhong

doi:10.1158/0008-5472.can-19-2332

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Tim-3 Hampers Tumor Surveillance of Liver-Resident and Conventional NK Cells by Disrupting PI3K Signaling.

Shared by NobleBlocks on Mar 1, 2020 • 12:00 AM UTC

Authors:

Siyu Tan

Yong Xu

Zehua Wang

Abstract

Natural killer (NK) cells are enriched within the liver. Apart from conventional NK (cNK) cells, recent studies identified a liver-resident NK (LrNK) subset, which constitutes about half of hepatic NK cells and exhibits distinct developmental, phenotypic, and functional features. However, it remains...

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