Use of &gt;100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations.

MH, Kowalski; H, Qian; Z, Hou; JD, Rosen; AL, Tapia; Y, Shan; D, Jain; M, Argos; DK, Arnett; C, Avery; KC, Barnes; LC, Becker; SA, Bien; JC, Bis; J, Blangero; E, Boerwinkle; DW, Bowden; S, Buyske; J, Cai; MH, Cho; SH, Choi; H, Choquet; LA, Cupples; M, Cushman; M, Daya; Vries PS, de; PT, Ellinor; N, Faraday; M, Fornage; S, Gabriel; SK, Ganesh; M, Graff; N, Gupta; J, He; SR, Heckbert; B, Hidalgo; CJ, Hodonsky; MR, Irvin; AD, Johnson; E, Jorgenson; R, Kaplan; SLR, Kardia; TN, Kelly; C, Kooperberg; JA, Lasky-Su; RJF, Loos; SA, Lubitz; RA, Mathias; CP, McHugh; C, Montgomery; JY, Moon; AC, Morrison; ND, Palmer; N, Pankratz; GJ, Papanicolaou; JM, Peralta; PA, Peyser; SS, Rich; JI, Rotter; EK, Silverman; JA, Smith; NL, Smith; KD, Taylor; TA, Thornton; HK, Tiwari; RP, Tracy; T, Wang; ST, Weiss; LC, Weng; KL, Wiggins; JG, Wilson; LR, Yanek; S, Zöllner; KE, North; PL, Auer; LM, Raffield; AP, Reiner; Y, Li

doi:10.1371/journal.pgen.1008500

Public

Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations.

Published in PLoS genetics • Dec 23, 2019

NobleIDark:/48914/w1/20260526/B8D80045Record on NobleID

Authors:

Kowalski MH

,

Qian H

,

Hou Z

Abstract

Most genome-wide association and fine-mapping studies to date have been conducted in individuals of European descent, and genetic studies of populations of Hispanic/Latino and African ancestry are limited. In addition, these populations have more complex linkage disequilibrium structure. In order to...

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