A recombinant platform for flavivirus vaccines and diagnostics using chimeras of a new insect-specific virus

Hobson‐Peters, Jody; J. Harrison, Jessica; Watterson, Daniel; E. Hazlewood, Jessamine; J. Vet, Laura; D. Newton, Natalee; Warrilow, David; M. G. Colmant, Agathe; Taylor, Carmel; Huang, Bixing; B. H. Piyasena, Thisun; K. Chow, Weng; Xiang Setoh, Yin; Tang, Bing; Nakayama, Eri; Yan, Kexin; A. Amarilla, Alberto; Wheatley, Sarah; R. Moore, Peter; Finger, Mitchell; Kurucz, Nina; Modhiran, Naphak; R. Young, Paul; A. Khromykh, Alexander; Bielefeldt‐Ohmann, Helle; Suhrbier, Andreas; A. Hall, Roy

doi:10.1126/scitranslmed.aax7888

Public

A recombinant platform for flavivirus vaccines and diagnostics using chimeras of a new insect-specific virus

Published in Science Translational Medicine • Dec 11, 2019

Authors:

Jody Hobson‐Peters

Jessica J. Harrison

Daniel Watterson

Abstract

mouse models). BinJ/VIF-prME viruses thus represent a versatile, noninfectious (for vertebrate cells), high-yield technology for generating chimeric flavivirus particles with low biocontainment requirements.

Subject

Flavivirus

Virology

Virus

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