Stiffness of cationized gelatin nanoparticles is a key factor determining RNAi efficiency in myeloid leukemia cells

Zhang, Weiqi; Hoon Han, Bo; Lai, Xinning; Xiao, Chen; Xu, Shilin; Meng, Xianghui; Li, Zifu; Meng, Jie; Wen, Tao; Yang, Xiangliang; Liu, Jian; Xu, Haiyan

doi:10.1039/c9cc09068a

Public

Stiffness of cationized gelatin nanoparticles is a key factor determining RNAi efficiency in myeloid leukemia cells

Published in Chemical Communications • Dec 18, 2019

Authors:

Weiqi Zhang

Bo Hoon Han

Xinning Lai

Abstract

Here we demonstrated that the stiffness of cationized gelatin nanoparticles determined the efficiency of RNAi in myeloid leukemia cells when the particle size and surface charges were kept constant. The siRNA delivery system with an elastic modulus of 0.87 MPa showed the largest siRNA uptake and RNA...

Subject

Myeloid leukemia

RNA interference

Gelatin

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