Pharmacokinetics and safety of aztreonam/avibactam for the treatment of complicated intra-abdominal infections in hospitalized adults: results from the REJUVENATE study

A. Cornely, Oliver; Miguel Cisneros, José; Torre‐Cisneros, Julián; Jesús Rodríguez-Hernández, María; Tallón‐Aguilar, Luis; Calbo, Esther; Pablo Horcajada, Juan; Queckenberg, Christian; Zettelmeyer, Ulrike; Arenz, Dorothee; Rosso-Fernández, Clara; Jiménez‐Jorge, Silvia; Turner, Guy; Raber, Susan; O’Brien, Seamus; Luckey, Alison; Cristina Padial Aguado, Ana; Montejo Baranda, M.; García Bernedo, Carlos; Bludau, Marc; Boix-Palop, Lucía; Cheng, Karen; de Jonge, Boudewijn; Javier González de Molina, Francisco; Retamar, Pilar; Guzmán-Puche, Julia; Palomo Jiménez, Virginia; Antonio López-Ruiz, José; Montero-Mateos, Enrique; Roca-Oporto, Cristina; Piessen, Guillaume; Postil, D.; M. Jiménez Rodríguez, R.; Padillo–Ruiz, Javier; Rupp, Jan; Morales-Soriano, Rafael; Wible, Michele; Cano Yuste, Angela; Gómez-Zorrilla, Sílvia

doi:10.1093/jac/dkz497

Public

Pharmacokinetics and safety of aztreonam/avibactam for the treatment of complicated intra-abdominal infections in hospitalized adults: results from the REJUVENATE study

Published in Journal of Antimicrobial Chemotherapy • Dec 6, 2019

Authors:

Oliver A. Cornely

José Miguel Cisneros

Julián Torre‐Cisneros

Abstract

OBJECTIVES: To investigate pharmacokinetics (PK) and safety (primary objectives) and efficacy (secondary objective) of the investigational monobactam/β-lactamase inhibitor combination aztreonam/avibactam in patients with complicated intra-abdominal infection (cIAI). METHODS: This Phase 2a open-label...

Subject

Aztreonam

Medicine

Avibactam

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