Insertions and Duplications in the Polyproline Region of the Hepatitis E Virus

Lhomme, Sébastien; Nicot, Florence; Jeanne, Nicolas; Dimeglio, Chloé; Roulet, Alain; Lefèbvre, Caroline; Carcenac, Romain; Manno, Maxime; Dubois, Martine; Péron, Jean‐Marie; Alric, Laurent; Kamar, Nassim; Abravanel, Florence; Izopet, Jacques

doi:10.3389/fmicb.2020.00001

Public

Insertions and Duplications in the Polyproline Region of the Hepatitis E Virus

Published in Frontiers in Microbiology • Jan 31, 2020

Authors:

Sébastien Lhomme

Florence Nicot

Nicolas Jeanne

Abstract

Recombinant strains of hepatitis E virus (HEV) with insertions of human genomic fragments or HEV sequence duplications in the sequence encoding the polyproline region (PPR) were previously described in chronically infected patients. Such genomic rearrangements confer a replicative advantage in vitro...

Subject

Biology

Genome

Viral quasispecies

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