MiR-199a-modified exosomes from adipose tissue-derived mesenchymal stem cells improve hepatocellular carcinoma chemosensitivity through mTOR pathway

Lou, Guohua; Chen, Liang; Xia, Caixia; Wang, Weina; Qi, Jinjin; Li, Aichun; Zhao, Liying; Chen, Zhi; Zheng, Min; Liu, Yanning

doi:10.1186/s13046-019-1512-5

Public

MiR-199a-modified exosomes from adipose tissue-derived mesenchymal stem cells improve hepatocellular carcinoma chemosensitivity through mTOR pathway

Published in Journal of Experimental & Clinical Cancer Research • Jan 2, 2020

Authors:

Guohua Lou

Liang Chen

Caixia Xia

Abstract

BACKGROUND: MiR-199a-3p (miR-199a) can enhance the chemosensitivity of hepatocellular carcinoma (HCC). Because of the easy degradation of miRNA by direct infusion, effective vehicle-mediated delivery of miR-199a may represent a new strategy for improving HCC chemotherapy. Considering mesenchymal ste...

Subject

Microvesicles

Exosome

Doxorubicin

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