Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases

A. de Jesus, Adriana; Hou, Yangfeng; R. Brooks, Stephen; Malle, Louise; Biancotto, Angélique; Huang, Yan; R. Calvo, Katherine; Marrero, Bernadette; Moir, Susan; J. Oler, Andrew; Deng, Zuoming; A. Montealegre Sanchez, Gina; Ahmed, Amina; J. Allenspach, Eric; Arabshahi, Bita; M. Behrens, Edward; M. Benseler, Susanne; Bezrodnik, Liliana; Bout‐Tabaku, Sharon; C. Brescia, AnneMarie; E. Brown, Diane; M. Burnham, Jon; Soledad Caldirola, María; Carrasco, Ruy; Chan, Alice; Cimaz, Rolando; Dancey, Paul; Dare, Jason; DeGuzman, Marietta; R. Dimitriades, Victoria; Ferguson, Ian; J. Ferguson, Polly; S. Finn, Laura; Gattorno, Marco; A. Grom, Alexei; P. Hanson, Eric; J. Hashkes, Philip; M. Hedrich, Christian; Herzog, Ronit; Horneff, Gerd; Jerath, Rita; A. Kessler, Elizabeth; Kim, Hanna; Kingsbury, D.; M. Laxer, Ronald; Y. Lee, Pui; Ae Lee‐Kirsch, Min; B. Lewandowski, Laura; C. Li, Suzanne; Lilleby, Vibke; Mammadova, Vafa; N. Moorthy, Lakshmi; Nasrullayeva, Gulnara; M. O’Neil, Kathleen; Onel, Karen; Özen, Seza; Pan, Nancy; Pillet, Pascal; Gerent Petry Piotto, Daniela; Punaro, Marilynn; Reiff, Andreas; Reinhardt, Adam; G. Rider, Lisa; Rivas‐Chacon, Rafael; Ronis, Tova; Rösen‐Wolff, Angela; Roth, Johannes; M. Ruth, Natasha; Rygg, Marite; Schmeling, Heinrike; S. Schulert, Grant; Scott, Christiaan; Seminario, Gisella; Shulman, Andrew; Sivaraman, Vidya; Beth F. Son, Mary; Stepanovskiy, Yuriy; Stringer, Elizabeth; Mansfield Taber, Sara; Teresa Terreri, Maria; J. Tifft, Cynthia; R. Torgerson, Troy; L. Tosi, Laura; van Royen‐Kerkhof, Annet; Wampler Muskardin, Theresa; Canna, Scott; Goldbach‐Mansky, Raphaela

doi:10.1172/jci129301

Public

Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases

Published in Journal of Clinical Investigation • Dec 24, 2019

Authors:

Adriana A. de Jesus

Yangfeng Hou

Stephen R. Brooks

Abstract

BACKGROUNDUndifferentiated systemic autoinflammatory diseases (USAIDs) present diagnostic and therapeutic challenges. Chronic interferon (IFN) signaling and cytokine dysregulation may identify diseases with available targeted treatments.METHODSSixty-six consecutively referred USAID patients underwen...

Subject

Cytokine

Interferon

Immunology

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