Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats

Chika Onwordi, Ellis; F. Halff, Els; Whitehurst, Thomas; Mansur, Ayla; Côtel, Marie-Caroline; Wells, Lisa; Creeney, Hannah; R. Bonsall, David; Rogdaki, Maria; Shatalina, Ekaterina; Reis Marques, Tiago; A. Rabiner, Eugenii; N. Gunn, Roger; Natesan, Sridhar; C. Vernon, Anthony; Howes, Oliver

doi:10.1038/s41467-019-14122-0

Public

Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats

Published in Nature Communications • Jan 14, 2020

Authors:

Ellis Chika Onwordi

Els F. Halff

Thomas Whitehurst

Abstract

Abstract Synaptic dysfunction is hypothesised to play a key role in schizophrenia pathogenesis, but this has not been tested directly in vivo. Here, we investigated synaptic vesicle glycoprotein 2A (SV2A) levels and their relationship to symptoms and structural brain measures using [ 11 C]UCB-J posi...

Subject

Schizophrenia (object-oriented programming)

Hippocampus

Hippocampal formation

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