Innate immune priming in the absence of TAK1 drives RIPK1 kinase activity–independent pyroptosis, apoptosis, necroptosis, and inflammatory disease

K. Subbarao Malireddi, R.; Gurung, Prajwal; Kesavardhana, Sannula; Samir, Parimal; R. Burton, Amanda; Mummareddy, Harisankeerth; Vogel, Peter; William Pelletier, S.; Burgula, Sandeepta; Kanneganti, Thirumala‐Devi

doi:10.1084/jem.20191644

Public

Innate immune priming in the absence of TAK1 drives RIPK1 kinase activity–independent pyroptosis, apoptosis, necroptosis, and inflammatory disease

Published in The Journal of Experimental Medicine • Dec 23, 2019

Authors:

R. K. Subbarao Malireddi

Prajwal Gurung

Sannula Kesavardhana

Abstract

RIPK1 kinase activity has been shown to be essential to driving pyroptosis, apoptosis, and necroptosis. However, here we show a kinase activity-independent role for RIPK1 in these processes using a model of TLR priming in a TAK1-deficient setting to mimic pathogen-induced priming and inhibition. TLR...

Subject

Pyroptosis

Necroptosis

RIPK1

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