Innate immune priming in the absence of TAK1 drives RIPK1 kinase activity–independent pyroptosis, apoptosis, necroptosis, and inflammatory disease

Subbarao Malireddi, R.K.; Gurung, Prajwal; Kesavardhana, Sannula; Samir, Parimal; Burton, Amanda; Mummareddy, Harisankeerth; Vogel, Peter; Pelletier, Stephane; Burgula, Sandeepta; Kanneganti, Thirumala-Devi

doi:10.1084/jem.20191644

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Innate immune priming in the absence of TAK1 drives RIPK1 kinase activity–independent pyroptosis, apoptosis, necroptosis, and inflammatory disease

Shared by NobleBlocks on Dec 23, 2019 • 12:00 AM UTC

Authors:

R.K. Subbarao Malireddi

Prajwal Gurung

Sannula Kesavardhana

Abstract

RIPK1 kinase activity has been shown to be essential to driving pyroptosis, apoptosis, and necroptosis. However, here we show a kinase activity–independent role for RIPK1 in these processes using a model of TLR priming in a TAK1-deficient setting to mimic pathogen-induced priming and inhibition. TLR...

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