An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors

Reinhard, Katharina; Rengstl, Benjamin; Oehm, Petra; Michel, Kristina; Billmeier, Arne; Hayduk, Nina; Klein, Oliver; Kuna, Kathrin; Ouchan, Yasmina; Wöll, Stefan; Christ, Elmar; Weber, David; Suchan, Martin; Bukur, Thomas; Birtel, Matthias; Jahndel, Veronika; Mroz, Karolina; Hobohm, Kathleen; Kranz, Lena; Diken, Mustafa; Kühlcke, Klaus; Türeci, Özlem; Sahin, Ugur

doi:10.1126/science.aay5967

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An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors

Shared by NobleBlocks on Jan 24, 2020 • 12:00 AM UTC

Authors:

Katharina Reinhard

Benjamin Rengstl

Petra Oehm

Abstract

A one-two, CAR-T cell punch Chimeric antigen receptor (CAR)–T cells have been clinically effective in killing certain hematological malignancies, but achieving long-term patient responses for solid tumors remains a challenge. Reinhard et al. describe a two-part “CARVac” strategy to overcome poor CAR...

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