An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors

Reinhard, Katharina; Rengstl, Benjamin; Oehm, Petra; Michel, Kristina; Billmeier, Arne; Hayduk, Nina; Klein, Oliver; Kuna, Kathrin; Ouchan, Yasmina; Wöll, Stefan; Christ, Elmar; Weber, David; Suchan, M; Bukur, Thomas; Birtel, Matthias; Jahndel, Veronika; Mroz, Karolina; Hobohm, Kathleen; M. Kranz, Lena; Diken, Mustafa; Kühlcke, Klaus; Türeci, Özlem; Şahin, Uğur

doi:10.1126/science.aay5967

Public

An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors

Published in Science • Jan 3, 2020

Authors:

Katharina Reinhard

Benjamin Rengstl

Petra Oehm

Abstract

Chimeric antigen receptor (CAR)-T cells have shown efficacy in patients with B cell malignancies. Yet, their application for solid tumors has challenges that include limited cancer-specific targets and nonpersistence of adoptively transferred CAR-T cells. Here, we introduce the developmentally regul...

Subject

Chimeric antigen receptor

Claudin

RNA

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