miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer

Parashar, Deepak; Geethadevi, Anjali; R. R. Aure, Miriam; Mishra, Jyotsna; George, Jasmine; Chen, Changliang; K. Mishra, Manoj; Tahiri, Andliena; Zhao, Wei; Nair, Bindu; Lu, Yiling; S. Mangala, Lingegowda; Rodriguez‐Aguayo, Cristian; Lopez‐Berestein, Gabriel; K.S. Camara, Amadou; Liang, Mingyu; S. Rader, Janet; Ramchandran, Ramani; You, Ming; K. Sood, Anil; N. Kristensen, Vessela; B. Mills, Gordon; Pradeep, Sunila; Chaluvally–Raghavan, Pradeep

doi:10.1016/j.celrep.2019.11.085

Public

miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer

Published in Cell Reports • Dec 1, 2019

Authors:

Deepak Parashar

Anjali Geethadevi

Miriam R. R. Aure

Abstract

Genomic amplification of 3q26.2 locus leads to the increased expression of microRNA 551b-3p (miR551b-3p) in triple-negative breast cancer (TNBC). Our results demonstrate that miR551b-3p translocates to the nucleus with the aid of importin-8 (IPO8) and activates STAT3 transcription. As a consequence,...

Subject

Triple-negative breast cancer

Oncostatin M

Breast cancer

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