Exosome‐delivered circRNA promotes glycolysis to induce chemoresistance through the miR‐122‐PKM2 axis in colorectal cancer

Wang, Xinyi; Zhang, Haiyang; Yang, Haiou; Bai, Ming; Ning, Tao; Deng, Ting; Liu, Rui; Fan, Qian; Zhu, Kegan; Li, Jialu; Zhan, Yang; Ying, Guoguang; Ba, Yi

doi:10.1002/1878-0261.12629

Public

Exosome‐delivered circRNA promotes glycolysis to induce chemoresistance through the miR‐122‐PKM2 axis in colorectal cancer

Published in Molecular Oncology • Jan 4, 2020

Authors:

Xinyi Wang

Haiyang Zhang

Haiou Yang

Abstract

Malignant tumors, including colorectal cancer (CRC), usually rely on ATP generation through aerobic glycolysis for both rapid growth and chemotherapy resistance. The M2 isoform of pyruvate kinase (PKM2) has a key role in catalyzing glycolysis, and PKM2 expression varies even within a single tumor. I...

Subject

PKM2

Exosome

Glycolysis

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