Control of protein function through oxidation and reduction of persulfidated states

Dóka, Éva; Ida, Tomoaki; Dagnell, Markus; Abiko, Yumi; Cong Luong, Nho; Balog, Noémi; Takata, Tsuyoshi; Espinosa, Belén; Nishimura, Akira; Cheng, Qing; Funato, Yosuke; Miki, Hiroaki; M. Fukuto, Jon; R. Prigge, Justin; E. Schmidt, Edward; S.J. Arnér, Elias; Kumagai, Yoshito; Akaike, Takaaki; Nagy, Péter

doi:10.1126/sciadv.aax8358

Public

Control of protein function through oxidation and reduction of persulfidated states

Published in Science Advances • Jan 1, 2020

Authors:

Éva Dóka

Tomoaki Ida

Markus Dagnell

Abstract

H species are abundant in mouse liver and enzymatically regulated by the glutathione and thioredoxin systems and (ii) deletion of the thioredoxin-related protein TRP14 in mice altered CysSSH levels on a subset of proteins, predicting a role for TRP14 in persulfide signaling. Furthermore, selenium su...

Subject

Reduction (mathematics)

Oxidation reduction

Function (biology)

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