N 6 -methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription

Liu, Jun; Dou, Xiaoyang; Chen, Chuanyuan; Chen, Chuanyuan; Chen, Chuan; Chen, Chuan; Liu, Chang; Xu, Meng; Zhao, Siqi; Shen, Bin; Gao, Yawei; Han, Dali; He, Chuan

doi:10.1126/science.aay6018

Public

N 6 -methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription

Published in Science • Jan 16, 2020

Authors:

Jun Liu

Xiaoyang Dou

Chuanyuan Chen

Abstract

A new layer of transcriptional control N 6 -methyladenosine (m 6 A) is the most abundant messenger RNA modification in almost all eukaryotes. Liu et al. now show that m 6 A is also cotranscriptionally added onto various chromosome-associated regulatory RNAs (carRNAs) in mammalian cells. Disruption o...

Subject

Chromatin

Transcription (linguistics)

RNA

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