PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase

D’Hulst, Gommaar; Soro-Arnáiz, Inés; Masschelein, Evi; Veys, Koen; Fitzgerald, Gillian; Smeuninx, Benoit; Kim, Sung‐Hoon; Deldicque, Louise; Blaauw, Bert; Carmeliet, Peter; Breen, Leigh; Koivunen, Peppi; Zhao, Shimin; De Bock, Katrien

doi:10.1038/s41467-019-13889-6

Public

PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase

Published in Nature Communications • Jan 10, 2020

Authors:

Gommaar D’Hulst

Inés Soro-Arnáiz

Evi Masschelein

Abstract

Abstract mTORC1 is an important regulator of muscle mass but how it is modulated by oxygen and nutrients is not completely understood. We show that loss of the prolyl hydroxylase domain isoform 1 oxygen sensor in mice (PHD1 KO ) reduces muscle mass. PHD1 KO muscles show impaired mTORC1 activation in...

Subject

Leucine

Hydroxylation

mTORC1

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