Engineered exosomes for targeted co-delivery of miR-21 inhibitor and chemotherapeutics to reverse drug resistance in colon cancer

Liang, Gaofeng; Zhu, Yanliang; Jaffar Ali, Doulathunnisa; Tian, Tian; Xu, Huantian; Si, Ke; Sun, Bo; Chen, Baoan; Xiao, Zhongdang

doi:10.1186/s12951-019-0563-2

Public

Engineered exosomes for targeted co-delivery of miR-21 inhibitor and chemotherapeutics to reverse drug resistance in colon cancer

Published in Journal of Nanobiotechnology • Jan 9, 2020

Authors:

Gaofeng Liang

Yanliang Zhu

Doulathunnisa Jaffar Ali

Abstract

Abstract Background 5-Fluorouracil (5-FU) has been commonly prescribed for patients with colorectal cancer (CRC), but resistance to 5-FU is one of the main reasons for failure in CRC. Recently, microRNAs (miRNAs) have been established as a means of reversing the dilemma by regulating signaling pathw...

Subject

Microvesicles

Exosome

Cancer research

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