O-GlcNAcylation of PGK1 coordinates glycolysis and TCA cycle to promote tumor growth

Nie, Hao; Ju, Haixing; Fan, Jiayi; Shi, Xiaoliu; Cheng, Yaxian; Cang, Xiaohui; Zheng, Zhiguo; Duan, Xiaotao; Yi, Wen

doi:10.1038/s41467-019-13601-8

Public

O-GlcNAcylation of PGK1 coordinates glycolysis and TCA cycle to promote tumor growth

Published in Nature Communications • Jan 7, 2020

Authors:

Hao Nie

Haixing Ju

Jiayi Fan

Abstract

Many cancer cells display enhanced glycolysis and suppressed mitochondrial metabolism. This phenomenon, known as the Warburg effect, is critical for tumor development. However, how cancer cells coordinate glucose metabolism through glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle is l...

Subject

Glycolysis

Citric acid cycle

Warburg effect

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