Polyphyllin VI Induces Caspase-1-Mediated Pyroptosis via the Induction of ROS/NF-κB/NLRP3/GSDMD Signal Axis in Non-Small Cell Lung Cancer

Teng, Jin‐Feng; Mei, Qibing; Zhou, Xiaogang; Tang, Yong; Xiong, Rui; Qiu, Wenqiao; Pan, Rong; Yuen Kwan Law, Betty; Kam Wai Wong, Vincent; Yu, Chong‐Lin; Long, Hanan; Xiao, Xiuli; Zhang, Feng; Wu, Jianming; Qin, Dalian; Wu, Anguo

doi:10.3390/cancers12010193

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Polyphyllin VI Induces Caspase-1-Mediated Pyroptosis via the Induction of ROS/NF-κB/NLRP3/GSDMD Signal Axis in Non-Small Cell Lung Cancer

Published in Cancers • Jan 13, 2020

Authors:

Jin‐Feng Teng

Qibing Mei

Xiaogang Zhou

Abstract

Trillium tschonoskii Maxim (TTM), a traditional Chinese medicine, has been demonstrated to have a potent anti-tumor effect. Recently, polyphyllin VI (PPVI), a main saponin isolated from TTM, was reported by us to significantly suppress the proliferation of non-small cell lung cancer (NSCLC) via the ...

Subject

Pyroptosis

Inflammasome

Apoptosis

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