Functional brain architecture is associated with the rate of tau accumulation in Alzheimer’s disease

Franzmeier, Nicolai; Neitzel, Julia; Rubinski, Anna; Smith, Ruben; Strandberg, Olof; Ossenkoppele, Rik; Hansson, Oskar; Ewers, Michael; Disease Neuroimaging Initiative (ADNI), Alzheimer’s; Weiner, Michael; Aisen, Paul; C. Petersen, Ronald; R. Jack, Clifford; J. Jagust, William; Q. Trojanowki, John; W. Toga, Arthur; Beckett, Laurel; C. Green, Robert; J. Saykin, Andrew; C. Morris, John; M. Shaw, Leslie; Liu, Enchi; Montine, Tom; G. Thomas, Ronald; Donohue, Michael; Walter, Sarah; Gessert, Devon; Sather, Tamie; Jiminez, Gus; Harvey, Danielle; Donohue, Michael; A. Bernstein, Matt; C. Fox, Nick; M. Thompson, Paul; Schuff, Norbert; DeCarli, Charles; Borowski, Bret; Gunter, Jeff; L. Senjem, Matthew; Vemuri, Prashanthi; T. Jones, David; Kantarci, Kejal; Ward, Chad; A. Koeppe, Robert; Foster, Norm; M. Reiman, Eric; Chen, Kewei; Mathis, Chet; Landau, Susan; J. Cairns, Nigel; Householder, Erin; Taylor Reinwald, Lisa; Lee, Virginia; Korecka, Magdalena; Figurski, Michal; Crawford, Karen; Neu, Scott; Foroud, Tatiana; Potkin, Steven; Shen, Li; Faber, Kelley; Eun Kim, Sung; Nho, Kwangsik; Kachaturian, Zaven; Frank, Richard; J. Snyder, Peter; Molchan, Susan; Kaye, Jeffrey; F. Quinn, Joseph; Lind, Betty; Carter, Raina; Dolen, Sara; S. Schneider, Lon; Pawluczyk, Sonia; Beccera, Mauricio; Teodoro, Liberty; M. Spann, Bryan; B. Brewer, James; Vanderswag, Helen; Fleisher, Adam; L. Heidebrink, Judith; Lord, Joanne; C. Petersen, Ronald; S. Mason, Sara; S. Albers, Colleen; S. Knopman, David; Johnson, Kris; S. Doody, Rachelle; Villanueva Meyer, Javier; Chowdhury, Munir; Rountree, Susan; Dang, Mimi; Stern, Yaakov; S. Honig, Lawrence; L. Bell, Karen; M. Ances, Beau; C. Morris, John; Carroll, Maria; Leon, Sue; Householder, Erin; A. Mintun, Mark; Schneider, Stacy; OliverNG, Angela; Griffith, Randall; W. Clark, David; Geldmacher, David; Brockington, John; D. Roberson, Erik; Grossman, Hillel; Mitsis, Effie; deToledo‐Morrell, Leyla; C. Shah, Raj; Duara, Ranjan; Varón, Daniel; T. Greig, Maria; Roberts, Peggy; Albert, Marilyn; U. Onyike, Chiadi; D’Agostino, Daniel; Kielb, Stephanie; E. Galvin, James; M. Pogorelec, Dana; Cerbone, Brittany; A. Michel, Christina; Rusinek, Henry; J. de Leon, Mony; Glodzik, Lidia; De Santi, Susan; Murali Doraiswamy, P.; R. Petrella, Jeffrey; Z. Wong, Terence; E. Arnold, Steven; Karlawish, Jason; A. Wolk, David; D. Smith, Charles; A. Jicha, Gregory; Hardy, Peter; Sinha, Partha; Oates, Elizabeth; Conrad, Gary; L. López, Oscar; Oakley, MaryAnn; M. Simpson, Donna; P. Porsteinsson, Anton; S. Goldstein, Bonnie; Martin, Kim; M. Makino, Kelly; Saleem Ismail, M.; Brand, Connie; A. Mulnard, Ruth; Thai, Gaby; Mc Adams Ortiz, Catherine; Womack, Kyle; Mathews, Dana; Quiceno, Mary; Diaz Arrastia, Ramon; King, Richard; Weiner, Myron; Martin Cook, Kristen; D. Devous, Michael; I. Levey, Allan; J. Lah, James; S. Cellar, Janet; M. Burns, Jeffrey; S. Anderson, Heather; H. Swerdlow, Russell; G. Apostolova, Liana; Tingus, Kathleen; Woo, Ellen; Silverman, Daniel; H. Lu, Po; Bartzokis, George; R. Graff Radford, Neill; ParfittH, Francine; Kendall, Tracy; Johnson, Heather; R. Farlow, Martin; Marie Hake, Ann; R. Matthews, Brandy; Herring, Scott; Hunt, Cynthia; H. van Dyck, Christopher; E. Carson, Richard; G. MacAvoy, Martha; Chertkow, Howard; Bergman, Howard; Hosein, Chris; E. Black, Sandra; Stefanovic, Bojana; Caldwell, Curtis; Robin Hsiung, Ging‐Yuek; Feldman, Howard; Mudge, Benita; Assaly Past, Michele; Kertesz, Andrew; Rogers, John; Trost, Dick; Bernick, Charles; Munic, Donna; Kerwin, Diana; Marsel Mesulam, Marek; Lipowski, Kristine; Wu, Chuang; Johnson, Nancy; Sadowsky, Carl; Martínez, Walter; Villena, Teresa; Scott Turner, Raymond; Johnson, Kathleen; Reynolds, Brigid; A. Sperling, Reisa; A. Johnson, Keith; A. Marshall, Gad; Frey, Meghan; A. Yesavage, Jerome; L. Taylor, Joy; Lane, Barton; Rosen, Allyson; Tinklenberg, Jared; N. Sabbagh, Marwan; M. Belden, Christine; A. Jacobson, Sandra; A. Sirrel, Sherye; W. Kowall, Neil; Killiany, Ronald; E. Budson, Andrew; Norbash, Alexander; Lynn Johnson, Patricia; O. Obisesan, Thomas; Wolday, Saba; Allard, Joanne; J. Lerner, Alan; Ogrocki, Paula; Hudson, Leon; Fletcher, Evan; Carmichael, Owen; Olichney, John; DeCarli, Charles; Kittur, Smita; Borrie, Michael; Y Lee, T; Bartha, Robert; C. Johnson, Sterling; Asthana, Sanjay; M. Carlsson, Cynthia; G. Potkin, Steven; Preda, Adrian; Nguyen, Dana; N. Tariot, Pierre; Fleisher, Adam; Reeder, Stephanie; Bates, Vernice; Capote, Horacio; Rainka, Michelle; W. Scharre, Douglas; Kataki, Maria; Adeli, Anahita; A. Zimmerman, Earl; Celmins, Dzintra; D. Brown, Alice; D. Pearlson, Godfrey; Blank, Karen; Anderson, Karen; B. Santulli, Robert; J. Kitzmiller, Tamar; S. Schwartz, Eben; M. SinkS, Kaycee; D. Williamson, Jeff; Garg, Pradeep; Watkins, Franklin; R. Ott, Brian; Querfurth, Henry; Tremont, Geoffrey; Salloway, Stephen; Malloy, Paul; Correia, Stephen; J. Rosen, Howard; L. Miller, Bruce; Mintzer, Jacobo; Spicer, Kenneth; Bachman, David; Finger, Elizabeth; Pasternak, Stephen; Rachinsky, Irina; Rogers, John; Kertesz, Andrew; Drost, Dick; Pomara, Nunzio; Hernando, Raymundo; Sarrael, Antero; K. Schultz, Susan; L. Boles Ponto, Laura; Shim, Hyungsub; E. Smith, Karen; Relkin, Norman; Chaing, Gloria; Raudin, Lisa; Smith, Amanda; Fargher, Kristin; Ashok Raj, Balebail

doi:10.1038/s41467-019-14159-1

Public

Functional brain architecture is associated with the rate of tau accumulation in Alzheimer’s disease

Published in Nature Communications • Jan 17, 2020

Authors:

Nicolai Franzmeier

Julia Neitzel

Anna Rubinski

Abstract

In Alzheimer's diseases (AD), tau pathology is strongly associated with cognitive decline. Preclinical evidence suggests that tau spreads across connected neurons in an activity-dependent manner. Supporting this, cross-sectional AD studies show that tau deposition patterns resemble functional brain ...

Subject

Alzheimer's disease

Disease

Neuroscience

Research Assistant

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