Hyperthermia induced by transient receptor potential vanilloid-1 (TRPV1) antagonists in human clinical trials: Insights from mathematical modeling and meta-analysis

Garami, András; P. Shimansky, Yury; Rumbus, Zoltán; Cristiano Lillo Vizin, Robson; Farkas, Nelli; Hegyi, Judit; Szakács, Zsolt; Solymár, Margit; Csenkey, Alexandra; Chiche, D.; P. Kapil, Ram; J. Kyle, Donald; D. Van Horn, Wade; Hegyi, Péter; A. Romanovsky, Andrej

doi:10.1016/j.pharmthera.2020.107474

Public

Hyperthermia induced by transient receptor potential vanilloid-1 (TRPV1) antagonists in human clinical trials: Insights from mathematical modeling and meta-analysis

Published in Pharmacology & Therapeutics • Jan 9, 2020

Authors:

András Garami

Yury P. Shimansky

Zoltán Rumbus

Abstract

Antagonists of the transient receptor potential vanilloid-1 (TRPV1) channel alter body temperature (Tb) in laboratory animals and humans: most cause hyperthermia; some produce hypothermia; and yet others have no effect. TRPV1 can be activated by capsaicin (CAP), protons (low pH), and heat. First-gen...

Subject

TRPV1

Transient receptor potential channel

Hyperthermia

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