Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock

Fujii, Tomoko; Luethi, Nora; J. Young, Paul; Frei, Daniel; M. Eastwood, Glenn; French, Craig; M. Deane, Adam; Shehabi, Yahya; Abrahão Hajjar, Ludhmila; Oliveira, Gisele; Udy, Andrew; Orford, Neil; J. Edney, Samantha; Hunt, Anna; L. Judd, Harriet; Bitker, Laurent; Cioccari, Luca; Naorungroj, Thummaporn; Yanase, Fumitaka; Bates, Samantha; McGain, Forbes; P. Hudson, Elizabeth; Al‐Bassam, Wisam; Bhatia Dwivedi, Dhiraj; Peppin, Chloe; McCracken, Phoebe; Orosz, Judit; Bailey, Michael; Bellomo, Rinaldo; the VITAMINS Trial Investigators, for

doi:10.1001/jama.2019.22176

Public

Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock

Published in JAMA • Jan 17, 2020

Authors:

Tomoko Fujii

Nora Luethi

Paul J. Young

Abstract

Importance: It is unclear whether vitamin C, hydrocortisone, and thiamine are more effective than hydrocortisone alone in expediting resolution of septic shock. Objective: To determine whether the combination of vitamin C, hydrocortisone, and thiamine, compared with hydrocortisone alone, improves th...

Subject

Medicine

Thiamine

Hydrocortisone

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