Cancer Stem Cell Marker DCLK1 Correlates with Tumorigenic Immune Infiltrates in the Colon and Gastric Adenocarcinoma Microenvironments

Wu, Xiangyan; Qu, Dongfeng; Weygant, Nathaniel; Peng, Jun; W. Houchen, Courtney

doi:10.3390/cancers12020274

Public

Cancer Stem Cell Marker DCLK1 Correlates with Tumorigenic Immune Infiltrates in the Colon and Gastric Adenocarcinoma Microenvironments

Published in Cancers • Jan 22, 2020

Authors:

Xiangyan Wu

Dongfeng Qu

Nathaniel Weygant

Abstract

Immunotherapy that has proven efficacy in several solid cancers plays a partial role in improving clinical outcomes of advanced gastrointestinal (GI) cancers. There is an unmet need to find new immune-related therapeutic targets. Doublecortin-like kinase 1 (DCLK1) marks tuft cells which are recogniz...

Subject

Immune system

Colorectal cancer

Immunotherapy

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