Genomic and epigenomic EBF1 alterations modulate TERT expression in gastric cancer

Xing, Manjie; Fong Ooi, Wen; Tan, Jing; Qamra, Aditi; Lee, Po-Hsien; Li, Zhimei; Xu, Chang; Padmanabhan, Nisha; Quan Lim, Jing; Amanda Guo, Yu; Yao, Xiaosai; Mandoli, Amit; Moy Ng, Ley; Sheng, Taotao; Wang, Jing; Kyon Huang, Kie; George Anene-Nzelu, Chukwuemeka; Wei Ting Ho, Shamaine; Ray, Mohana; Ma, Lijia; E. Fazzi, Gregorio; Lim, Kevin; Wijaya, Giovani; Zhang, Shenli; Nandi, Tannistha; Yan, Tingdong; Mei Chang, Mei; Das, Kakoli; Fazreen Adam Isa, Zul; Wu, Jeanie; Suk Yean Poon, Polly; Ning Lam, Yue; Suling Lin, Joyce; Ting Tay, Su; Hui Lee, Ming; Lay Keng Tan, Angie; Ong, Xuewen; P. White, Kevin; Rozen, Steve; Beer, M; Foo, Roger; I. Grabsch, Heike; J. Skanderup, Anders; Li, Shang; Tean Teh, Bin; Tan, Patrick

doi:10.1172/jci126726

Public

Genomic and epigenomic EBF1 alterations modulate TERT expression in gastric cancer

Published in Journal of Clinical Investigation • May 3, 2020

Authors:

Manjie Xing

Wen Fong Ooi

Jing Tan

Abstract

Transcriptional reactivation of telomerase catalytic subunit (TERT) is a frequent hallmark of cancer, occurring in 90% of human malignancies. However, specific mechanisms driving TERT reactivation remain obscure for many tumor types and in particular gastric cancer (GC), a leading cause of global ca...

Subject

Epigenomics

Cancer

Expression (computer science)

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