Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake

J. Jakobi, Arjen; T. Huber, Stefan; A. Mortensen, Simon; W. Schultz, Sebastian; Palara, Anthimi; Kuhm, Tanja; Kumar Shrestha, Birendra; Lamark, Trond; J. H. Hagen, Wim; Wilmanns, Matthias; Johansen, Terje; Brech, Andreas; Sachse, Carsten

doi:10.1038/s41467-020-14343-8

Public

Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake

Published in Nature Communications • Jan 23, 2020

Authors:

Arjen J. Jakobi

Stefan T. Huber

Simon A. Mortensen

Abstract

p62/SQSTM1 is an autophagy receptor and signaling adaptor with an N-terminal PB1 domain that forms the scaffold of phase-separated p62 bodies in the cell. The molecular determinants that govern PB1 domain filament formation in vitro remain to be determined and the role of p62 filaments inside the ce...

Subject

Cell biology

Autophagy

Intermediate filament

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