PET Molecular Imaging of Phosphodiesterase 10A: An Early Biomarker of Huntington's Disease Progression.

P, Fazio; CJ, Fitzer-Attas; L, Mrzljak; J, Bronzova; S, Nag; JH, Warner; B, Landwehrmeyer; N, Al-Tawil; C, Halldin; A, Forsberg; J, Ware; V, Dilda; A, Wood; C, Sampaio; A, Varrone

doi:10.1002/mds.27963

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PET Molecular Imaging of Phosphodiesterase 10A: An Early Biomarker of Huntington's Disease Progression.

Shared by NobleBlocks on Jan 22, 2020 • 12:00 AM UTC

Authors:

Fazio P

Fitzer-Attas CJ

Mrzljak L

Abstract

Background Changes in phosphodiesterase 10A enzyme levels may be a suitable biomarker of disease progression in Huntington's disease.Objectives To evaluate phosphodiesterase 10A PET imaging as a biomarker of HD progression using the radioligand, [18 F]MNI-659.Methods The cross-sectional study (NCT02...

Subject

Biomarker

Imaging

Huntington's disease

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