PET Molecular Imaging of Phosphodiesterase 10A: An Early Biomarker of Huntington's Disease Progression

Fazio, Patrik; Fitzer‐Attas, Cheryl; Mrzljak, Ladislav; Bronzova, Juliana; Nag, Sangram; Harley Warner, John; Bernhard Landwehrmeyer, G.; Al‐Tawil, Nabil; Halldin, Christer; Forsberg, Anton; J. Ware, Jennifer; Dilda, Valentina; Wood, Andrew; Sampaio, Cristina; Varrone, Andrea; the PEARL‐HD and LONGPDE10 study collaborators, for

doi:10.1002/mds.27963

Public

PET Molecular Imaging of Phosphodiesterase 10A: An Early Biomarker of Huntington's Disease Progression

Published in Movement Disorders • Jan 22, 2020

Authors:

Patrik Fazio

Cheryl Fitzer‐Attas

Ladislav Mrzljak

Abstract

Abstract Background Changes in phosphodiesterase 10A enzyme levels may be a suitable biomarker of disease progression in Huntington's disease. Objectives To evaluate phosphodiesterase 10A PET imaging as a biomarker of HD progression using the radioligand, [ 18 F]MNI‐659. Methods The cross‐sectional ...

Subject

Biomarker

Phosphodiesterase

Disease

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