Eplerenone for chronic central serous chorioretinopathy in patients with active, previously untreated disease for more than 4 months (VICI): a randomised, double-blind, placebo-controlled trial

Lotery, Andrew; Sivaprasad, Sobha; O’Connell, Abby; A Harris, Rosie; Culliford, Lucy; Ellis, Lucy; J. Cree, Angela; Madhusudhan, Savita; Béhar‐Cohen, Francine; Chakravarthy, Usha; Pető, Tünde; Rogers, Chris; C Reeves, Barnaby; Bellani, Samir; Griffiths, Helen; Thulasidharan, Suresh; Watkins, Catrin; Kaye, Rebecca; Menon, Deepthy; April Neville, Qin; Denham, Rebecca; Gillvray, Karen; Abugreen, Salwa; Nixon, Natalie; Alarbi, Mohammed; Ghanchi, Faruque; Madanat, Zeid; Hawes, Nicola; G. Hughes, Edward; Keir, Campbell; Kisza, Krystian; Bailey, Clare; Hazlewood, Phillippa; Cloake, Julie; Menon, Geeta; Chandran, Manju; Raguro, Abigail; Mohamed, Moin; Sing Lim, Wei; Eleftheriadis, Haralabos; Efraimidis, Stefanos; McKibbin, Martin; Mukherjee, Rajarshi; A. P. Wilson, Joanne; M. Lenfestey, P.; Harding, Simon; Haigh, Kelly; Chhabra, Ramandeep; Horani, Mania; Platt, Raisa-Marie; Talks, James; Bhatia, Devanga; Andrews, Violet; M. Downes, Susan; Samuel, Ivy; Buttress, Daniel; Pagliarini, Sergio; Randle, Linzi; Allison, Jeanette; Brand, Christopher; Edwards, Maria; Karia, Niral; Shipman, Maria; Thompson, E; Kotagiri, Ajay; Steel, David; J. Dodds, Steven; Turner, Steve; Osoba, Yinka; Criddle, Sharon; C. Yang, Yit; Narendran, Niro; Karpoor, Meena; Gale, Richard; Airody, Archana; Grice-Holt, Alison

doi:10.1016/s0140-6736(19)32981-2

Public

Eplerenone for chronic central serous chorioretinopathy in patients with active, previously untreated disease for more than 4 months (VICI): a randomised, double-blind, placebo-controlled trial

Published in The Lancet • Jan 1, 2020

Authors:

Andrew Lotery

Sobha Sivaprasad

Abby O’Connell

Abstract

BACKGROUND: In chronic central serous chorioretinopathy (CSCR), fluid accumulates in the subretinal space. CSCR is a common visually disabling condition that develops in individuals up to 60 years of age, and there is no definitive treatment. Previous research suggests the mineralocorticoid receptor...

Subject

Medicine

Eplerenone

Placebo

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