Zika virus infection leads to mitochondrial failure, oxidative stress and DNA damage in human iPSC-derived astrocytes

Flores Ledur, Pítia; Karmirian, Karina; da S. G. Pedrosa, Carolina; R. Q. Souza, Letícia; Lemos, Gabriela; Martino, Thiago; de Cassia Cavalheiro Gomes Ferreira, Jéssica; Ferreira de Azevedo Reis, Gabriel; dos Santos Silva, Eduardo; Silva, Débora; Alexandre Salerno, José; M. Ornelas, Isis; Devalle, Sylvie; Madeiro da Costa, Rodrigo; Goto‐Silva, Livia; M. Higa, Luiza; Melo, Adriana; Tanuri, Amílcar; Chimelli, Leila; Massao Murata, Marcos; P. Garcez, Patrícia; Cremonese Filippi‐Chiela, Eduardo; Galina, Antônio; L. Borges, Helena; K. Rehen, Stevens

doi:10.1038/s41598-020-57914-x

Public

Zika virus infection leads to mitochondrial failure, oxidative stress and DNA damage in human iPSC-derived astrocytes

Published in Scientific Reports • Jan 27, 2020

Authors:

Pítia Flores Ledur

Karina Karmirian

Carolina da S. G. Pedrosa

Abstract

Zika virus (ZIKV) has been extensively studied since it was linked to congenital malformations, and recent research has revealed that astrocytes are targets of ZIKV. However, the consequences of ZIKV infection, especially to this cell type, remain largely unknown, particularly considering integrativ...

Subject

Zika virus

Oxidative stress

Biology

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